Cyspera morning routine

Do not wash the skin before application: Unwashed skin has a natural hydrophilic film that helps prevent irritation.

1. Apply one pump of Cyspera® to the entire desired area (not a spot treatment) and leave for 15 minutes. If you have sensitive skin or are applying Cyspera® for the first time, start with an application time of 5 minutes for a few weeks and gradually increase the application time to 15 minutes (without exceeding 15 minutes).

2. Wash the area with a gentle cleanser. Gently pat the area dry. Apply moisturizer; keep skin hydrated throughout the day. Wear a broad-spectrum sunscreen (SPF 30 or higher) daily.

Avoid using retinol, AHA or prescription creams. Try our new NEW Cyspera Boost as a replacement for your moisturizer to increase your skin's luminosity and enhance the brightening results of Cyspera ®.

Cyspera evening routine

If you need to remove make-up or have a special need to wash your skin, wait at least 1 hour before applying Cyspera® and follow the steps above.

Intensive phase

Every day, once a day, for 15 minutes.

Maintenance phase

After 16 weeks of use, it is recommended to use Cyspera® twice a week, once a day for 15 minutes.

• Clinically proven to reduce pigmentation, dark spots and stubborn brown spots(1-7)
• The most tested cysteamine-based product in clinical trials (1-7): over 200 subjects recruited, 7 peer-reviewed publications
• Helps reduce the size and intensity of dark spots and limit the appearance of new spots
• Strong antioxidant effect
• Easy to use - can be integrated into your daily skin care routine.
• Gentle on the skin and suitable for all skin types and ethnicities
• Can be used on different parts of the body
• Hydroquinone-free and safe for permanent, long-term use
• Well tolerated and safe to use in summer
• Can be combined with aesthetic procedures(8-9)
• Cruelty free and not tested on animals.

VISIBLE RESULTS
Depigmenting effects

• 80% of melanin synthesis by cysteamine, demonstrated in in vitro studies(10)
• 67% reduction in the intensity of dark spots after 16 weeks of Cyspera® (2)
• 100% of subjects achieved visible effects after 16 weeks according to the investigator(2)
• 92% of subjects noticed visible effects after 16 weeks(2)

(1) Hsu, C., Mahdi, HA, Pourahmadi, M., & Ahmadi, S. (2013, April). Cysteamine cream as a new skin depigmenting product. In Journal of the American Academy of Dermatology (Vol. 68, No. 4, pp. AB189-AB189). 360

(2) Mansouri P, Farshi S, Hashemi Z, Kasraee B (2015). Evaluation of the efficacy of cysteamine 5% cream in the treatment of epidermal melasma: a randomized double-blind placebo-controlled trial. Br J Dermatol, 173(1), 209-217

(3) Farshi S, Mansouri P, Kasraee B (2018). Efficacy of cysteamine cream in the treatment of epidermal melasma, evaluated by Dermacatch as a new measurement method: a randomized double-blind placebo-controlled study. J Dermatologist Treat, 29(2), 182-189.

(4) Karrabi M, David, J, Sahebkar M. (2020). Clinical evaluation of efficacy, safety and tolerability of cysteamine 5% cream in comparison with modified Kligman's formula in subjects with epidermal melasma: A randomized, double‐blind clinical trial study. Skin Res Technol.

(5). Kasraee B, Mansouri, P Farshi, S. (2019). Significant therapeutic response to cysteamine cream in a melasma patient resistant to Kligman's formula. J Cosmet Dermatol, 18(1), 293-295.

(6) Nguyen J, Remyn L, Chung IY, Honigman A, Gourani‐Tehrani S, Wutami I, Rodrigues M. (2021). Evaluation of the efficacy of cysteamine cream compared to hydroquinone in the treatment of melasma: A randomized, double‐blinded trial. Australas J Dermatol, 62(1), e41-e46. (7) Karrabi M, Mansournia MA, Sharestanaki E, Abdollahnejad Y, Sahebkar M. (2020). Clinical evaluation of efficacy and tolerability of cysteamine 5% cream in comparison with tranexamic acid mesotherapy in subjects with melasma: a single-blind, randomized clinical trial study. Arch of Dermatol Res, 1-9.

(8) Marini L., Prime Journal, 2019 May/June 70–73

(9) Johnson B. et al. “Novel Combination of a 650-Microsecond Neodymium-doped Yttrium Aluminum Garnet 1,064-nm Laser and Cysteamine Cream for the Treatment of Melasma: A Case Study.” J Clin Aesthet Dermatol. 2020;13(3):28–30

(10) Qui L. et al, J. Invest Dermatol. 2000 Jan;114(1):21-7

Stabilized Cysteamine: Powerful antioxidant with proven effectiveness in improving the appearance of stubborn brown and dark spots. Safe and lasting even skin tone. Safe for long-term use

Niacinamide: Enhances the skin-lightening effect of cysteamine and ensures an even complexion.

Stabilized vitamin C: Provides a natural and healthy glow. Makes the skin appear more radiant over time

Cyspera Intensive™ Ingredients: Aqua, Paraffinum Liquidum, Cysteamine HCl, Niacinamide, Butyrospermum Parkii (Shea) butter, Glyceryl Stearate, Lecithin, Isopropyl Myristate, Cetyl Alcohol, Ceteareth-20, Ascorbyl Palmitate, Sodium Ascorbyl Phosphate, Octyldodecanol, Phenoxyethanol, Ethylhexylglycerin, Propylheptyl Caprylate C eteareth-12, Cetearyl alcohol, Cetyl Palmitate, Parfum (Fragrance), Xanthan Gum, PEG-30 dipolyhydroxystearate, Tocopherol, Beeswax, BHT, Tetrasodium EDTA, Hexyl Cinnamal, Linalool, Geraniol.

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